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Fr … May 20, Advances in nanotechnology-based platforms for survivin-targeted drug discovery George R, Hehlgans S, Kasher PR Zebrafish disease modeling holds the capacity and potential to significantly enhance the stroke drug development pipeline. However, for this system to be more widely acce … May 16, Approaches for targeting the mycobactin biosynthesis pathway for novel anti-tubercular drug discovery: where we stand Shyam M, Shilkar D, Jayaprakash V While the lack of iron supply can cripple bacterial growth and multiplication, excess iron can cause oxidative overload.

Constant up-regulation can strain the bacterial s … May 13, What are the challenges with multi-targeted drug design for complex diseases? Kaczor AA Despite numerous challenges resulting from the design of multi-target ligands, these efforts are worth making. Xie L In spite of successful application of advanced reinforcement learning techniques to target-based drug discovery, new reinforcement learning strategies are needed to addre … April 15, An overview of the preclinical discovery and development of trastuzumab deruxtecan: a novel gastric cancer therapeutic Kalmuk J, Rinder D, Spheroid-based 3D models represent one of the most used approaches to recapitulate the tumor environment, over … March 25, Recent in vivo advances of spirocyclic scaffolds for drug discovery Batista VF, Pinto DCGA, Areas covered: Following a brief overview of CHE pathogenesis and existing treatments, this review will outline the mechanisms and available data on emerging and investigational drugs currently being studied in clinical trials for the treatment of CHE.

Expert opinion: Immunomodulatory drugs such as topical and systemic JAK inhibitors and Th2-targeting antibodies such as dupilumab are currently under investigation for CHE treatment, with early promise. Management of CHE will likely move toward more targeted treatments through clinical trials and away from broad immunosuppressants such as cyclosporine and methotrexate, which have previously been investigated for CHE and have more side effects.

In coming years, CHE patients may benefit from a wider range of both topical and systemic therapeutics that target immune pathways relevant to the various CHE subtypes. Keywords: AFX; chronic hand eczema; delgocitinib; dupilumab; gusacitinib; roflumilast; ruxolitinib.